Why Choose Hormone Pellet Therapy?

When the body requires hormone replacement therapy or hormone optimization, several delivery methods are available to meet one’s needs. Hormone pills, patches, creams, gels, injections and/or pellets are available by prescription only. Each method has its pluses and minuses. However, hormone pellet therapy provides the most bio-available, bio-identical and bio-utilized hormone therapy. Ideally, best to consult  one of Holistique’s hormone therapy specialists about which options may be most effective and most suitable for you particularly and your lifestyle.

Pellet Therapy

Pellet therapy is amongst the oldest forms of hormone therapy, dating back to the 1930s. With the many advancements in technology, pellet therapy is now considered the most effective delivery method of bioidentical hormone therapy,  and the most preferred option among most patients and providers.

Which Hormones are Available in Pellets?

Pellet therapy is available for bio-identical estradiol and bio-identical testosterone hormones, although other hormones may be compounded into pellets as well. Most commonly, testosterone with or without estradiol pellets are used for women and testosterone only pellets for men, each at individualized doses.

These bio-identical hormone pellets, derived from yams, are compounded into tiny pellets and inserted into the upper layer of skin, in the love handles for men, and below the waist line in the buttocks for women. Aside from the convenience of never having to remember to take a pill, slathering on cream, or putting on a patch, this delivery method is the most optimal for a natural dosing structure and bioavailability. Pellets placed in fat tissue release hormones directly into the blood stream, bypassing first-pass liver metabolism, making them biochemically significantly safer and superior than oral testosterone and oral estrogens.

Why Use Pellet Therapy as Your First Choice of Therapy?

Pellet therapy mimics the slow, steady dosing that occurs naturally within the ovaries or testicles of the human body. Hormones from the pellet implants release according to activity level. For example, when stress levels or physical activity is high, pellets release more hormones into the blood stream. And when activity is low, such as during sleep, minimal hormones are released into the blood stream. Utilizing blood and urine lab tests, symptom assessment, lifestyle and activity level, medical history, and reaction to past therapy, by using a patented pellet dosage calculator, hormone pellet dosages individualized to optimize your particular body are prescribed. Pellet therapy is designed to meet the unique needs of the individual, so you get exactly what your body needs, and when it needs it–much like nature intended.

Holistique Pellet Therapy

After much research and experience of administering pellet therapy for the past 15 years, we have engaged and excelled our pellet implant procedural technique through Evexipel. Not all hormone pellets are made the same. When pressed horizontally during the compounding process, after implanted horizontally pressed hormone pellets release more evenly throughout their course of time unlike pellets that are compounded using the vertical method (which is the method used for compounding all the other pellets available on the market). Vertical pressing creates an inconsistent hormone release especially near the end of their time. Using a horizontal method as in Evexipel, the releasing of hormones from the pellets occurs gradually and evenly providing continual relief of symptoms until the next time pellets are due to be inserted. Secondly, Evexipel’s unique formulation and implanting method is a safe atraumatic technique that significantly reduces risks of extrusions, scarring and inflammation at the implant site.

How Often Do I Need to Be Pelleted?

Pelleting is a science and an art. Depending on your activity level, stress, exercise, age, dosage, etc, pellets can be utilized by the body quickly or slowly. On the average, most women over age of 40 need hormone pellets implanted every 3 months while men over age 40 typically need the procedure every 5-6 months. Initially, it may take an average of 2-3 pellet procedures over the course of one year to achieve optimum hormone balance and symptom control.


Hormone pellet therapy offers the most stable bio-available dosing of bio-identical hormones that is safe and effective in maintain hormone optimization. Pellet therapy is ideal for reducing menopause and androgen deficiency symptoms while improving wellness and health.  To learn if and which bio-identical hormone therapy, especially pellet therapy, is right for you, please consult one of our Hormone Therapy Specialists.












Nooshin K. Darvish, ND

Leave a Comment

eighteen − ten =

Stay up-to-date with the latest clinic news

We respect your privacy. Your information will never be shared with third parties.